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However, its inhibition activates cell ferroptosis, a non-apoptotic iron-dependent mechanism of cell death, leading to an effective anticancer effect

In horses, Vitamin B6 is synthesized to some extent by hindgut microbes but may require dietary support under conditions of high metabolic demand, such as intense training, growth, or recovery

Using dicer-substrate small interfering RNA (dsiRNAs), we specifically knocked down mRNA expression of each of these (Figure S5A), resulting in all cases in a surprisingly robust diminishment of the NADPH/NADP+ ratio (Figure S5B)