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In STZ-induced DN mouse kidney sections, the outer mitochondrial membrane ruptured, mitochondrial crista disappeared, ACSL4 expression was significantly increased, the levels of oxidative products were elevated, and the level of GPX4 was decreased, indicating that ferroptosis was involved in STZ-induced DN [225]

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Acetylcysteine solution probably protects the liver by maintaining or restoring the glutathione levels, or by acting as an alternate substrate for conjugation with, and thus detoxification of, the reactive metabolite