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Moreover, overexpression of mucin MUC13 exacerbates TJ dysfunction through the janus kinase 1 (JAK1)/signal transducer and activator of transcription 3 (STAT3) and rho-associated coiled-coil containing protein kinase 2 (ROCK2)/mitogen-activated protein kinase (MAPK) signaling pathways, and IL-22 can activate these pathways [73]

The biallelic inactivation of FH leads to hereditary leiomyomatosis and renal cell cancer (HLRCC), a hereditary cancer syndrome characterized by the presence of benign tumours of the skin and uterus, and a highly malignant form of renal cell cancer 1

Certain small lymph-borne molecules ( 70 kDa) soluble lymph-borne molecules, such as antibodies, cannot enter the reticular conduit system because of physical constraints imposed by the dimensions of the diaphragms guarding the conduit openings and by the spacing of collagen fibers at the core of the reticular conduits (7, 9, 11, 12)

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