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In other studies, phenytoin was used as a reagent to treat mouse embryos because it causes oxidation of DNA, proteins, and lipids, likely due to increased production of OH radicals ( Part IV: reactive oxygen species and oxidative damage in endometriosis Proximity of gametes and embryos to ROS from inflammatory response ROS are in female oviductal fluid and PF and function as normal signaling modulators of ovulation, embryo development and implantation ( Endometriomas create physical blockages and can impede normal fluid flow and motility in the oviduct, the peritoneum and the vicinity of the ovary, facilitating the buildup of refluxed blood and its components

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Health 25 , 163168 (2022)