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8) Sousa D, Carmo H, Roque BR, et al

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In general, a platform or oral first line DMT (fl-DMT) was offered unless any of the following circumstances occurred: (i) two clinical attacks in a year, (ii) a clinical attack and/or a new gadolinium-enhanced lesion (GEL) within a year, or (iii) a disabling clinical attack with residual EDSS of at least 2 points in the pyramidal system