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This works by inhibiting tyrosinase, an enzyme involved in the production of melanin (the pigment for both skin and hair)

Notably, pharmacological inhibition of either AMPK or autophagy partially restores cell viability but fails to rescue ATP levels, suggesting that hyperactivated mitophagy consumes residual functional mitochondria, thus perpetuating a deleterious feedback loop 32

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Adaptation of training materials, development of cases, and training of standardized patients were conducted by the interdisciplinary UCLA Advance Care Planning Program ( Fellows were asked to complete surveys pre- and post-training, which included questions about demographics and prior training [pre-, N=6], session feedback [post-, N=7], and validated items assessing self-reported clinician barriers to goals of care communication [pre- and post-, N=36]