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To determine whether targeting riboflavin processing has in vivo antileukemic efficacy, we took advantage of a previous in vivo CRISPR screening platform established in our laboratory, which employed a 200 gene library enriched for AML dependencies, and which included sgRNAs targeting RFK 24

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There are other forms of bias in these datasets including channeling (e.g., the prescribing pattern depends on a patient characteristic (particularly diabetes or obesity) that is a PDAC risk factor), detection (e.g., overreporting due to additional testing to rule out a suspected adverse event (e.g., imaging triggered by pancreas enzyme elevations)), and Weber effect (initial increase in event reporting shortly after drug launch) 49