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Methods: MUP-uPA mice (MUP mice) were used as the NASH model, and a conditional KrasG12D model (KC mice: LSL-Kras G12D/+ ;PDX-1-Cre ) was used as the pancreatic Kras mutation model

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The scientific rationale for peptide-based fat loss research centers on several key mechanisms: Lipolysis Activation: Peptides that increase cAMP in adipocytes (fat cells) activate hormone-sensitive lipase (HSL), which catalyzes the breakdown of stored triglycerides into free fatty acids a process called lipolysis