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Molecular mechanisms mediating inflammation in vascular disease

Fernandes A, Cao S, Parsons E, Bogetic D, Kumar D, Rogers J et al (2024) Clinical and mechanistic findings from MOTIF Trial: a phase 2 study using food allergen oral immunotherapy for cashew or shrimp allergy

Growth Factor Gene Expression Growth factor gene expression increases substantially across multiple pathways: VEGF (Vascular Endothelial Growth Factor) Shows dose-dependent increases in mesenchymal stem cells, promoting angiogenesis and blood vessel formation bFGF (Basic Fibroblast Growth Factor) Increases 230% when combined with LED irradiation at 625-635 nm wavelengths BDNF (Brain-Derived Neurotrophic Factor) Receives stimulation for nerve outgrowth and neurological support ANGPT1 (Angiopoietin 1) Increases 487% for vascular stabilization BMP-2 (Bone Morphogenetic Protein 2) Receives upregulation for bone tissue regeneration Inflammatory Pathway Suppression Inflammatory pathway suppression occurs through multiple mechanisms

In summary, CaOx-exo exacerbated inflammation and kidney injury induced by kidney stones by promoting M1 polarization and METs release