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Description

2019;85:e00671-e719

74 KalpageH

In addition, BV2 cells treated with siRNA for HACE1 showed increased neurotoxicity during co-culture with SH-SY5Y cells compared to vehicle treated BV2 cells, indicating the neuroprotective effect of this protein [237]

All this suggests clock genes, especially BMAL1, as a strong candidate in the pathogenesis of the possible COVID-19-induced acceleration of aging, with a potential role for iron disruption and ferroptosis