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Dipy (v.1.5.0) [60] was applied over the corrected DWIs to fit both second order tensors and intravoxel orientation distribution functions (ODF) via the Simple Harmonic Oscillator-based Reconstruction and Estimation method (SHORE) [61]

These include: copy number loss of C-terminal Src homology 2 Adapter Protein 2 (SHC2) 9 , SNCA gene (synuclein alpha) single-nucleotide polymorphisms 10,11 and mutation in the CoQ2 gene which encodes for 4 hydroxbenzoate polyprenyltransferase (CoQ2), an enzyme involved in coenzyme Q10 (CoQ10) biosynthesis 12,13