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In vivo biodistribution behavior DiR (Meilunbio, Dalian, Liaoning, China) was used to load the NPs and investigate in vivo biodistribution

[Abstract]2024 Sep 13;15(9):1206

Conversely, SIRT2 activation may decrease acetylation of PEPCK 1, enhancing its stability, while deacetylating FOXO1 and PGC-1 to upregulate transcription of glucose metabolism-related bio-enzymes, resulting in the inhibition of gluconeogenesis (43)