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Glutathione, a powerful antioxidant that destroys harmful oxidizing agents in cells, is composed of glutamic acid, cysteine, and glycine, and has the following structure: glutathione What is unusual about the peptide bond between glutamic acid and cysteine
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Importantly, the lumen of the ER represents a more oxidizing environment than the cytoplasm, with a higher ratio of oxidized to reduced glutathione (GSSG/GSH
