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Evidence linking diet and cancer Diet was a prevalent explanation for many diseases even as far back as 168 BC when the physician Galen first highlighted its involvement in cancer growth

Additionally, stromal cells, such as CAFs, contribute to this environment by restricting the infiltration and effectiveness of antitumor T cells and dendritic cells, creating an imbalance between pro-tumor and antitumor cells

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The NF-B pathway functions as a central pro-survival and pro-inflammatory transcription factor that promotes tumor progression by suppressing tumor suppressors such as phosphatase and tensin homolog (PTEN), thereby indirectly enhancing PI3K/AKT signaling and supporting cancer cell viability