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347,348 High glucose levels inhibit the PI3K/Akt pathway in Schwann cells, leading to overexpression of DNA methyltransferases (DNMT1 and DNMT3a) and upregulation of thioredoxin-interacting protein (TXNIP)

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She'd already read up on books about nutrition and had a pretty good idea about the so-called "cave-man" diet, having restocked her kitchen with whole foods, whole grains and eliminated flour, artificial flavors, colors, preservatives, sugar, artificial sweeteners, hydrogenated or partially hydrogenated oils, and she used practically no canned stuff