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& Sanjar, S

While early studies centred on cases obtained from institutionalised psychiatric settings [92, 93, 98], cases were later recruited through internal research registers [64], multiple centres [47, 50, 64, 70, 71, 88, 95, 96] or community advertisements [75]

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Therefore, some researchers evaluated the growth dependence of osteosarcoma on leucine and found that blocking leucine uptake by using the leucine structural analog N-acetylleucinamide (NALA) will cause the downregulation of mTORC1 and thus affect tumor development [70]