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Description

GLS1, Glutaminase 1

This bolstered chemoresistance in cancer cells is partially supported by glutathione synthesis via glutaminolysis 86

This connection was also confirmed by Zhu et al.s (2018) group who found that upregulation of RIPK3 triggers ER stress which subsequently increased Ca 2+ overload and xanthine oxidase activity leading to overproduction of ROS, all of which was reduced by RIPK3 deletion