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Capsaicin in food application Chili peppers are integral to global culinary traditions and have a longstanding history of usage for food preservation, colouring, flavour enhancement, and medicinal applications

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4582-C THE PRESENCE OF FATTY LIVER IS ASSOCIATED WITH HIGHER TREATMENT RESPONSE IN PATIENTS WITH PRIMARY BILIARY CHOLANGITIS Leandro Sierra 1 , Romelia Barba Bernal 1 , Ana Marenco-Flores 1 , Bryan Ferrigno 2 , Daniela Goyes 3 , Wilfor Diaz Fernandez 2 , John Esli Medina Morales 4 , Alan Bonder 1 , Vilas Patwardhan 1 and ALD team, (1)Division of Gastroenterology and Hepatology, Beth Israel Deaconess Medical Center, Harvard Medical School, (2)Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, (3)Yale University Medical Center, New Haven, CT, United States, (4)Rutgers New Jersey Medical School, Kearny, NJ Background: Primary biliary cholangitis (PBC) is an autoimmune, chronic cholestatic liver disease involving bile ducts

found that PCa cells could activate downstream sterol regulatory element-binding protein 1 (SREBP1) and its transcriptional target stearoyl-CoA desaturase-1 (SCD1) through the PI3K/AKT/mTORC1 pathway to mediate monounsaturated fatty acids production