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doi:10.1016/j.fertnstert.2021.02.010

The OPLS-DA score plot showed a perfect clustering among the three groups, with acceptable values of predicted variance ( R 2 Y score = 0.87) and predictive ability ( Q 2 score = 0.61), indicating that the metabolites were significantly altered in plasma samples of thyroid nodules in comparison with healthy subjects (Figure 1A)