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In the context of impaired glutathione metabolism, two converging factors promote PGA accumulation

One report of a randomized controlled trial that allocated supplementation with vitamin D to infertile women with PCOS found that supplementation markedly reduced high-sensitivity C-reactive protein (hs-CRP) levels and increased total antioxidant capacity, indicating the potential of vitamin D to mitigate inflammation and oxidative stress in PCOS ( These findings also laid emphasis on how vitamin D influences multiple molecular aspects involved with the pathogenesis of PCOS

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4.3 Reduction of carcinogenic effects of chemical substances Selenium can prevent the metabolic activity of certain chemical carcinogens or antagonize their metabolites thereby inhibiting the carcinogenic effects of chemical carcinogens (138)