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In fact, environmental and lifestyle factors not only directly influence individuals, but also have transgenerational consequences, with parents potentially passing these effects on to their offspring [153]

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p 18 years with decompensated cirrhosis complicated by diuretic-resistant ascites defined as 1) inability to mobilize ascites despite maximum tolerated dose of diuretics, 2) rapid re-accumulation of ascites requiring serial large volume paracentesis (LVP) or 3) development of diuretic-related complications such as azotemia, electrolyte disturbances or hepatic encephalopathy