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Entrapment in -lactoglobulin and lactoferrin coacervates showed good protection for folic acid against degradation during storage treatments, such as freezing and freeze-drying 570,571

Serious symptoms (chest pain, severe headache, neurological changes, persistent mood changes) should prompt medical evaluation regardless of the supplement situation

In the absence of transfusion, patients with beta-thalassemia major die within the first five years of life, and even with transfusions, only 5065% of patients live beyond the age of 35 years in high-income countries [4], [5], [6]