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As ammonium concentrations are usually more than one order of magnitude lower than DON concentrations in the top 300 m of the Sargasso Sea 114 , DON overestimation due to omitting ammonium concentrations is inconsequential at the resolution of TDN at this site

Abbreviations Ach: Acetylcholine AchE: Acetylcholinesterase AD: Alzheimers disease AKBA: Acetyl-11-keto-beta-bosellic acid ALS: Amyotrophic lateral sclerosis ARE: Antioxidant response element Bcl-2: B-cell lymphoma 2 Bzip: Basic leucin zipper Caspase-3: Cysteine-aspartic proteases, cysteine aspartases or cysteine-dependent aspartate-directed proteases-3 CAT: Catalase FST: Forced swim test GABA: Gamma amino butyric acid GCL: Glutamate cysteine ligase GPx: Glutathione peroxidase GSH: Glutathione HD: Huntingtons disease HO-1: Hemeoxygenase 1 IL: Interleukin LDH: Lactate dehydrogenase MBP: Myelin basic protein MDA: Melanodialdehyde MeHg: Methylmercury MS: Multiple sclerosis MWM: Morris water maze NIT: Nitrite NQO1: NAD (P)H-quinone oxidoreductase 1 Nrf2: Nuclear erythroid 2 related factor OPCS: Oligodendrocytes PD: Parkinsons disease RNA: Reactive nitrogen species ROS: Reactive oxygen species SOD1: Superoxide dismutase 1 TSTQ: Time spend in target quadrant Txnrd1: Thioredoxin reductase 1 References Hubbard JA, Szu JI, Binder DK (2018) The role of aquaporin-4 in synaptic plasticity memory and disease

Insulin-like growth factor 1: common mediator of multiple enterotrophic hormones and growth factors

The alkalinity-induced stress for longer periods shows that metabolic profiles are significantly impacted by alkalinity exposure