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In other words, the effects are dose-dependent and include the classic opioid hazard of respiratory depression a key reason it is unsuitable for uncontrolled use

The clinical trial reported percentage weight loss rather than absolute weight, so researchers should calculate expected absolute weight changes based on the starting weight of their research subjects when designing study endpoints

Route of administration, as well as age, liver function and potential drug interactions (since melatonin is metabolized in the liver), may influence plasma melatonin levels and should be taken into account (115)

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