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The localized carbon dioxide ($CO_2$) gas pressures relax the pyloric sphincterthe physiological muscular valve separating the stomach cavity from the small intestine

Who should avoid this combination Individuals with a history of thyroid cancer or MEN 2 syndrome should not use tirzepatide, and therefore should not use this combination

[DOI] [PubMed] [Google Scholar] 157.Yamada Y., Kusakari Y., Akaoka M., Watanabe M., Tanihata J., Nishioka N., Bochimoto H., Akaike T., Tachibana T., Minamisawa S