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GBM is characterized by anaplasia, nuclear atypia, cellular pleomorphism, mitotic activity, and, most remarkably, alternated phases of rapid proliferation and aggressive invasion of the surrounding brain tissue, which inevitably leads to critical recurrence after surgical resection of the main tumor mass [3, 4]

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This approach offers a promising way to make chemotherapy more effective while reducing side effects (10)

Accordingly, the following sections examine the interplay between ferroptosis and inflammation and its disease-specific roles in atherosclerosis, myocardial ischemiareperfusion (I/R) injury, cardiomyopathies, heart failure and hypertention, among others