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Targeting metabolic transformation for cancer therapy

365,366,367,368 Ubx2, the ER-embedded ERAD component, assembles into a cluster on the outer mitochondrial membrane and engages Cdc48 to maintain the functional integrity of the translocase of the outer membrane (TOM) complex by preventing its obstruction upon the accumulation of translocation intermediates

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Interestingly, iPD PBMCs display a significant upregulation in mRNA expression of the respiratory chain subunits that compose complexes IV [58]