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1) Heart Disease In a meta-analysis of 19 studies with almost 20,000 people, high TMAO levels were associated with increased rates of cardiovascular diseases , such as heart failure and stroke

A choline analogue, 3,3-dimethylbutanol (DMB), has been uncovered with inhibitory effect to choline TMA lyase activity in turn decreasing circulating TMAO, and therefore attenuating the promoting role of choline in atherosclerosis (Wang et al., 2015)