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The apparent activation of the GHS-R1a receptor by Ipamorelin may lead to increased intracellular calcium ions through the phospholipase C pathway

On the other hand, Cys, an essential sulfur-containing amino acid, is involved in sensing and transducing changes in cellular redox states caused upon the generation of reactive oxygen species (ROS) and the presence of oxidized thiols

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This may potentially compromise mucosal protection and theoretically increase the risk of gastric irritation or ulceration