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Proposed Mechanism of Action In theory, the vaccine works by: Delivering mRNA instructions encoding tumour-related antigens Presenting these antigens to immune cells Activating cytotoxic T-cells Directing immune attack toward cancer cells Despite these theoretical mechanisms, several key questions remain unanswered: Which tumour antigens are targeted Which cancer types are included Whether immune activation leads to real tumour shrinkage How long the immune response lasts What side effects may occur

20 Studies have also revealed that MGST2 catalyzes the activation of GSH, resulting in the formation of a thiolate essential for both GSH peroxidase activity and GSH conjugation reactions with electrophilic substrates such as 1-chloro-2,4-dinitrobenzene

Nilsson K, Giovanella BC, Stehlin JS, Klein G

Menchaca, R