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Epithelial cells of inner and outer body surfaces (e.g., intestine, skin, and lung) are the first physical barrier which interacts with commensals and are also important producers of antimicrobial peptides and immune mediators that regulate immune homeostasis and host defense (186, 187)

The differentiation of T-cells into effector Th1, Th2, Th17, regulatory Treg cells, and cytotoxic CD8 + T-cells is modulated by distinct commensal microbiota, contributing to the maintenance of host immune balance ( Figure 5 )

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Fatigue, loss of appetite, and poor growth