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27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50 Early studies from our lab have shown the preferential expression of BCL-2 in AR -/lo PCSCs, 14,17 critical prosurvival functions of BCL-2 in PCa cells under nutrient deprivation and oxidative and genotoxic stresses, 29,32 and induction of BCL-2 in PCa models by chemotherapeutic drugs, castration and castration/Enza

The actions of MSCs are predominantly facilitated through three mechanisms: the release of paracrine factors, mitochondrial translocation, and the secretion of extracellular vesicles [131]