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In the DVT mouse model, endothelial activation and platelet function were stimulated by LPS but not by PAD4 deficiency, and PAD4 -/- mice formed NETs-free thrombi

In fact, these cells (neutrophil granulocytes, eosinophils, monocytes, macrophages, microglial cells) are equipped with a special enzymatic apparatus (NADPH oxidase) capable of generating superoxide and therefore use ROS to kill bacteria and neutralize viruses [34]