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coli strain MG1655 (DE3) into which we transformed the pET28-HBA plasmid (Supplementary Data 1) to enable it to synthesize HBA, resulting in strain FH001

consistent ~12-15% weight loss at 68 weeks Compound Tirzepatide (Zepbound) Class GIP/GLP-1 dual agonist FDA Status FDA-approved for chronic weight management Evidence Strength Phase 3 RCTs