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In a phase IIb data, patients receiving Lupuzor 200 g subcutaneously every 4 weeks achieved the SRI response at week 12 at higher rates than standard of care therapy that included stroids, antimalarials, azathioprine or methotrexate (53.1 vs

The imbalance in SCFA production due to dysbiosis of the flora, particularly decreased Bacteroidetes abundance, disrupt these regulatory mechanisms, contributing to portal hypertension (Toshida et al., 2023)

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To better understand the mechanisms of these disorders related to therapy, further research in the future is required on what causes the development of dysbiosis and depression, as well as drug-microbiota interactions