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(5421:) Sentrin-specific protease 8 (Sentrin/SUMO-specific protease SENP8)(Protease, cysteine 2) (NEDD8-specific protease 1) (Deneddylase-1)

Satarug S, orevi AB, Yimthiang S, Vesey DA, Gobe GC

Examples are accelerated glycolytic fluxes, ATP generation, a backup and diversion of glycolytic intermediates, the biosynthesis of nucleotides, the production of non-essential amino acids, lipids and hexosamines, maintenance of cellular redox homeostasis, low ROS formation, inhibition of pyruvate entry into mitochondria, lactate accumulation, stimulating sustained proliferation and suppression of anti-tumor immunity, and extracellular acidosis, which accelerates malignant progression and drives resistance to conventional therapies (Vaupel and Multhoff, 2021)

RhoGTPases at the synapse: an embarrassment of choice