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Results: In addition to increased hepatic triglyceride/cholesterol levels, global StarD5 knockout (StarD5 -/- ) mice displayed reduced plasma triglycerides and liver VLDL secretion as compared with wild type (WT) counterparts

Extremes of body weight have been shown to negatively affect the fecundability of females and adversely affect fetuses and embryos through oxidative mechanisms

The other limitation is that mitochondrial replacement therapy only addresses mitochondrial disorders resulting from a mutation in the mitochondrial genome, but not the nuclear genome