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Adverse Reactions/Side Effects The following adverse reactions are discussed in greater detail in other sections of the labeling: Myelosuppression [see Warnings and Precautions (5.1)] Renal failure [see Warnings and Precautions (5.2)] Bullous and exfoliative skin toxicity [see Warning and Precautions (5.3)] Interstitial pneumonitis [see Warnings and Precautions (5.4)] Radiation recall [see Warnings and Precautions (5.5)] 6.1 Clinical Trials Experience Because clinical trials are conducted under widely varying conditions, adverse reactions rates cannot be directly compared to rates in other clinical trials and may not reflect the rates observed in clinical practice

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Naltrexone : It blocks opioid effects and helps prevent the high associated with relapse

Sleep Med 21:140144 Piovezan RD, Jadczak AD, Tucker G, Visvanathan R (2023) Daytime sleepiness predicts mortality in nursing home residents: findings from the Frailty in Residential Aged Care Sector Over Time (FIRST) study