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HGF inhibitors Since HGF is the only known ligand of MET, formation of a HGF:MET complex blocks MET biological activity

Headaches have been reported, though distinguishing these from coincidental occurrences proves difficult

Figure 10 In addition to the sulfonamides, e.g., 40 and 41 , the spiro-oxindole dihydroquinazolinone derivative 42 was identified in the screening campaign and subsequently a large series of related analogues were made, e.g., by applying rapid MW-assisted reactions and thereafter examined as IRAP inhibitors in bioassays (Engen et al., 2020) (Figure 10)

Compounding pharmacies will need to wait to see the outcome of the July 23-24 meeting before being able to employ these bulk drug substances in compounding