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doi: 10.1038/s41409-018-0221-6 42 NegrinRS

Aging is associated with structural and functional changes in the mitochondria (Seo et al., 2016), which is accompanied by the alterations of biophysical properties of the membrane including alteration in the electron transport chain complex activities, decreased fluidity, and energy imbalance and mitochondrial failure (Tan et al., 2018)