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Oxidative stress induced by exogenous stimuli can also induce epigenetic alterations, since ROS can regulate the activity of epigenetic enzymes involved in DNA, RNA and histone modifications (319-321)

5 g/Kg) were determined 3 h, 6 h, and 9 h post oral gavage (n = 4 per group at each timepoint)

doi: 10.1007/BF03401781 39 SantosCXCStolfBSTakemotoPVAAmansoAMLopesLRSouzaEBet al

Research confirms that GH enhances mitochondrial oxidative capacity in skeletal muscle, with 16-35% increases in ATP production rate and citrate synthase activity, directly supporting the tissue's ability to utilize mobilized fatty acids as fuel