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Exhaled cysteinyl-leukotrienes and 8-isoprostane in patients with asthma and their relation to clinical severity

Effective targeting of MEK/ERK signaling at nanomolar concentrations by the novel small molecule inhibitor, PD0325901, in hematopoietic and solid tumors

10.1053/meta.2002.34017 28

however, these models consistently emphasize that predicted concentrations must be clinically verified through validated pain and comfort assessments rather than used as stand-alone dosing tools (114, 116)