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For instance, a prospective multi-ethnic cohort study found that populations with high daily intake of processed meats had a significantly higher risk of pancreatic cancer

Furthermore, TMAO exacerbates VC through dose-dependent vascular smooth muscle cell calcification and activation of the NLRP3 inflammasome and NF-B signaling (Zhang et al., 2020), thereby further promoting thrombosis (Figure 6)

Clinical studies have demonstrated that curcumin inhibits NLRP3 inflammasome activation via NF-B-induced P2X7R signalling in macrophages (Kong et al., 2016), and apigenin significantly reduces the mRNA and protein expression of TMAO-induced NLRP3 (Yamagata et al., 2019), which suggests that TCM could potentially treat CRC by impacting the NLRP3 inflammasome, providing a potential pathway

Studies are mixed as some research shows normal SHBG 20 , even with low thyroid hormone levels, but others show decreased SHBG 21