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10.3390/molecules27092826 50 DhanikJ.AryaN.NandV

In March 2026, Roche reported that the Phase 2 ZUPREME-1 trial produced mean body-weight reductions of up to 10.7% at week 42 versus 1.7% with placebo under the reported analysis

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Its still unclear which specific components of the NF-B signaling pathway are critical and how they might function during the differentiation of exhausted T cells