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Clinically the acute and chronic phases of PD are separate entities and have been seen to respond differently to similar treatments

A change in gene sequence can lead to a different amino acid being added to a polypeptide chain instead of the normal one

This process involves the sequestration and degradation of cellular components in a double-membrane structure called the autophagosome, which fuses with lysosomes leading to the degradation of the aggregates (Takahashi et al