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The function of three mPFC (medial prefrontal cortex) subregions, the anterior cingulate cortex (ACC), prelimbic cortex (PL), and infralimbic cortex (IL), is altered in PTSD (Pitman et al., 2012

Van Haren RM, Mehran R, Correa AM, Antonoff MB , Baker CM, Hofstetter WL, Mena GE, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Rice DC

This causes basal synaptic transmission.[ref] Rare genetic mutations in the GRIA1 gene are associated with intellectual disability and neurological disorders.[ref] Similarly, mutations that cause gain or loss of function in GRIA3 lead to neurodevelopmental disorders and seizures.[ref] Interestingly, AMPA receptors and glutamate are involved in the release of reproductive hormones from the brain, and these receptors control ovulation in women.[ref] Weak glutamate stimulation will cause the activation of AMPA receptors, while NMDA receptors require a strong stimulus

In the double-blind phase of the pivotal RCT, AEs and AE-related discontinuations were numerically more common with IPX203 compared to IR LD/CD treatment (42.2% vs 31.6%