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The current state of animal models in research: a review

doi: 10.1038/nri1604 54 DarnellJEJr.KerrlMStarkGR

This dysfunction is characterized by an abnormal enrichment of PUFA-containing triglycerides and phospholipids, alongside elevated acylcarnitines and specific long-chain ceramides, all of which strongly correlate with GAA repeat length and decreased FXN levels [104]

Additionally, ROS levels assessed 48 h post-exposure to CS using the DCFDA/H2DCFDA assay displayed a significant increase in the CS-exposed cells compared to CTRL samples (Fig