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Compared to the treatment with vitamins B1 and B6, the treatment with the combination of all three neurotropic B vitamins was 13.48% and 20.47% more effective, respectively

It has been described in publications that an analogue of this domain, AOD9604, can increase lipolytic sensitivity and affect the expression of receptors beta-3 adrenergic in adipose tissue, and increase fat oxidation and energy expenditure in animal models

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Notably, the P values for these genes were substantially more significant, and the fold changes in their differential expression levels were greater in the combination group than those in the single-natural product groups (Fig