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This impairment alters downstream AKT1 effectors including GSK3, FOXO, and mTOR, which are implicated in increased susceptibility to oxidative stress and neuronal death

Scientific data and sources Research summary Level of evidence Preliminary Number of included studies: 42 16 studies 10 studies 9 studies 4 studies 2 studies 1 study Final comment: Epitalon and thymulin are peptides with promising neuroprotective, immunomodulatory, and anti-cancer potential, but most available data come from animal studies and in vitro models

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These findings collectively deepen our understanding of the genetic interplay between TB and DM, emphasizing the need for integrative approaches that consider genetic, metabolic, and environmental factors in addressing TB-DM comorbidity