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Proton-pump inhibitors (e.g., omeprazole, esomeprazole, and lansoprazole), used to treat Zollinger-Ellison syndrome and gastroesophageal reflux disease (GERD), markedly decrease stomach acid secretion required for the release of vitamin B 12 from food but not from supplements

The native biosynthetic pathway of heme in E

However, mitochondrial oxidative phosphorylation decoupling agents had no effect on copper toxicity, indicating that mitochondrial respiration is crucial in the process of cuproptosis

Shin E-J, Jeong JH, Bing G, Park ES, Chae JS, Yen TPH, Kim W-K, Wie M-B, Jung B-D, Kim HJ, Lee S-Y, Kim H-C (2008) Kainate-induced mitochondrial oxidative stress contributes to hippocampal degeneration in senescence-accelerated mice